Season 4 · Now Streaming

The Frontier Podcast

Weekly conversations with the researchers, engineers, and founders building the future. From AI agents to fusion energy — deep dives into the technologies reshaping our world.

120 Episodes
4.5M Downloads
200+ Guests
4.9★ Rating
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Latest Episode S4 · E120
AI

The AI Agent Revolution: From Chatbots to Autonomous Systems

Andrej Karpathy on the transition from language models to autonomous AI agents — tool use, memory architectures, multi-agent coordination, and what it takes to build production-grade agent systems.

Andrej Karpathy Founder, Eureka Labs · Former Tesla AI Director
0:00 1:24:30
#AI Agents#LLMs#Production AI#AGI

Meet the Team

SC

Dr. Sarah Chen

Host & AI Research Lead

Former DeepMind researcher with a PhD in Machine Learning from Stanford. Covers AI, quantum, and computational breakthroughs.

MW

Marcus Webb

Co-host & Security Analyst

20-year cybersecurity veteran, former NSA, now advising Fortune 500s on Zero Trust and PQC migration.

JP

Dr. James Park

Co-host & Space Editor

Former SpaceX propulsion engineer. Covers launch vehicles, satellite constellations, and the lunar economy.

Recent Episodes

Episode Archive

Showing 104 episodes
The AI Agent Revolution: From Chatbots to Autonomous Systems
AI
#120 2026-07-08

The AI Agent Revolution: From Chatbots to Autonomous Systems

Andrej Karpathy

Founder, Eureka Labs

Play 1:24:30
Fusion at Q>10: Inside Commonwealth Fusion Systems
Fusion
#230 2026-07-01

Fusion at Q>10: Inside Commonwealth Fusion Systems

Bob Mumgaard

CEO & Co-founder

Play 58:12
Scaling Laws: Are They Dead or Still Holding?
AI
#121 2026-06-24

Scaling Laws: Are They Dead or Still Holding?

Sebastian Raschka

Independent LLM Researcher & Author

Play 1:15:42
Post-Quantum Cryptography: The 2030 Deadline
Cybersecurity
#130 2026-06-17

Post-Quantum Cryptography: The 2030 Deadline

Dr. Dustin Moody

Mathematician, PQC Lead

Play 47:38
CRISPR Cures: Three Years of Casgevy Long-Term Data
Biotech
#150 2026-06-10

CRISPR Cures: Three Years of Casgevy Long-Term Data

Dr. Haydar Frangoul

Principal Investigator

Play 52:15
Quantum Error Correction: Google's Surface Code Breakthrough
Quantum
#200 2026-06-03

Quantum Error Correction: Google's Surface Code Breakthrough

Dr. Hartmut Neven

VP of Engineering

Play 1:05:20
Solid-State Batteries at 500 Wh/kg: The Production Race
Energy Storage
#170 2026-05-27

Solid-State Batteries at 500 Wh/kg: The Production Race

Jagdeep Singh

CEO

Play 44:08
Open Source vs Closed Source LLMs: Who's Winning?
AI
#122 2026-06-10

Open Source vs Closed Source LLMs: Who's Winning?

Gabe Goodhart

AI Research Engineer

Play 1:02:15
China vs US: The AI Arms Race
AI
#123 2026-05-27

China vs US: The AI Arms Race

Jeffrey Ding

Assistant Professor of Political Science

Play 1:18:00
Will AI Replace Programmers? The Vibe Coding Revolution
AI
#124 2026-05-13

Will AI Replace Programmers? The Vibe Coding Revolution

Ethan Mollick

Professor at Wharton

Play 55:30
Reasoning Models: How Chain-of-Thought Changed AI
AI
#125 2026-04-29

Reasoning Models: How Chain-of-Thought Changed AI

Jason Wei

Research Scientist

Play 1:10:22
The Trillion Dollar AI Investment Pipeline
AI
#126 2026-04-15

The Trillion Dollar AI Investment Pipeline

Leopold Aschenbrenner

Founder

Play 48:45
AI Hardware Crisis: NVIDIA's Chip Dominance and Beyond
AI
#127 2026-04-01

AI Hardware Crisis: NVIDIA's Chip Dominance and Beyond

Kaoutar El Maghraoui

AI Hardware Researcher

Play 1:03:18
Multimodal AI: When Models See, Hear, and Speak
AI
#128 2026-03-18

Multimodal AI: When Models See, Hear, and Speak

Aaron Baughman

AI Engineer & Master Inventor

Play 57:12
RAG is Broken: How to Actually Build Production AI Systems
AI
#129 2026-03-04

RAG is Broken: How to Actually Build Production AI Systems

Greg Kamradt

AI Engineer & Educator

Play 49:55
Zero-Day Economics: The $25M Exploit Market
Cybersecurity
#131 2026-05-20

Zero-Day Economics: The $25M Exploit Market

Katie Moussouris

CEO & Founder

Play 48:00
AI vs AI: When Attackers Use LLMs for Phishing
Cybersecurity
#132 2026-04-22

AI vs AI: When Attackers Use LLMs for Phishing

Rachel Tobac

CEO & Ethical Hacker

Play 42:18
Zero Trust Architecture: Beyond the Buzzword
Cybersecurity
#133 2026-04-08

Zero Trust Architecture: Beyond the Buzzword

George Finney

CISO

Play 51:30
Ransomware as a Service: The Supply Chain Attack Epidemic
Cybersecurity
#134 2026-03-25

Ransomware as a Service: The Supply Chain Attack Epidemic

Allan Liska

Senior Security Architect

Play 46:22
Deepfake Detection: The Arms Race Against Synthetic Media
Cybersecurity
#135 2026-03-11

Deepfake Detection: The Arms Race Against Synthetic Media

Hany Farid

Professor of EECS

Play 44:08
Nation-State APTs: Tracking Advanced Persistent Threats
Cybersecurity
#136 2026-02-25

Nation-State APTs: Tracking Advanced Persistent Threats

Suzanne Spaulding

Director, Defending Democratic Institutions

Play 53:45
Cloud Security in the Multi-Cloud Era
Cybersecurity
#137 2026-02-11

Cloud Security in the Multi-Cloud Era

Tim Mackey

Principal Security Strategist

Play 41:15
The Cybersecurity Talent Gap: 4 Million Open Jobs
Cybersecurity
#138 2026-01-28

The Cybersecurity Talent Gap: 4 Million Open Jobs

Lynn Dohm

Executive Director

Play 38:50
Supply Chain Attacks: SolarWinds to npm Packages
Cybersecurity
#139 2026-01-14

Supply Chain Attacks: SolarWinds to npm Packages

Chris Hughes

Cybersecurity Resident Fellow

Play 45:30
Starship V3 and the Path to Mars
Space
#140 2026-06-10

Starship V3 and the Path to Mars

Tim Dodd

Spaceflight Communicator

Play 1:12:45
Artemis II: Returning Humans to the Moon
Space
#141 2026-05-06

Artemis II: Returning Humans to the Moon

Pamela Melroy

Deputy Administrator

Play 1:05:20
The Lunar Economy: Mining Water Ice at the South Pole
Space
#142 2026-04-22

The Lunar Economy: Mining Water Ice at the South Pole

Dr. Clive Neal

Planetary Geologist

Play 52:15
Europa Clipper: Searching for Life on Jupiter's Ocean Moon
Space
#143 2026-04-08

Europa Clipper: Searching for Life on Jupiter's Ocean Moon

Dr. Bonnie Buratti

Senior Research Scientist

Play 48:30
The Nancy Grace Roman Telescope: 100x Hubble's Field of View
Space
#144 2026-03-25

The Nancy Grace Roman Telescope: 100x Hubble's Field of View

Dr. Julie McEnery

Project Scientist

Play 44:18
Commercial Space Stations: The Post-ISS Era
Space
#145 2026-03-11

Commercial Space Stations: The Post-ISS Era

Mike Suffredini

CEO & President

Play 50:22
Satellite Constellations: Starlink, Kuiper, and the Orbital Gold Rush
Space
#146 2026-02-25

Satellite Constellations: Starlink, Kuiper, and the Orbital Gold Rush

Tim Farrar

Managing Director

Play 47:45
Direct-to-Device: When Satellites Connect Your Phone
Space
#147 2026-02-11

Direct-to-Device: When Satellites Connect Your Phone

Mark Matossian

Director of Space Systems

Play 41:12
Space Debris: The Kessler Syndrome and Orbital Cleanup
Space
#148 2026-01-28

Space Debris: The Kessler Syndrome and Orbital Cleanup

Lucas Pleney

Co-founder & CTO

Play 44:30
Voyager 1 at 50: Interstellar Mission Update
Space
#149 2026-01-14

Voyager 1 at 50: Interstellar Mission Update

Dr. Linda Spilker

Voyager Project Scientist

Play 38:15
AlphaFold 4 and the Protein Design Revolution
Biotech
#151 2026-05-20

AlphaFold 4 and the Protein Design Revolution

John Jumper

Director, AI for Science

Play 52:00
GLP-1 Revolution: Beyond Weight Loss to Addiction and Alzheimer's
Biotech
#152 2026-05-06

GLP-1 Revolution: Beyond Weight Loss to Addiction and Alzheimer's

Dr. Daniel Drucker

Senior Investigator

Play 49:15
AI-Driven Drug Discovery: From Years to Weeks
Biotech
#153 2026-04-22

AI-Driven Drug Discovery: From Years to Weeks

Daphne Koller

CEO & Founder

Play 46:30
mRNA Beyond COVID: Cancer Vaccines and Rare Diseases
Biotech
#154 2026-04-08

mRNA Beyond COVID: Cancer Vaccines and Rare Diseases

Dr. Katalin Karikó

Nobel Laureate & Professor

Play 51:08
The Biotech Bull Market: IPOs, M&A, and Investor Sentiment
Biotech
#155 2026-03-25

The Biotech Bull Market: IPOs, M&A, and Investor Sentiment

Stephen Hansen

Director of Biopharma Intelligence

Play 44:22
Organoids and NAMs: Replacing Animal Testing in Drug Discovery
Biotech
#156 2026-03-11

Organoids and NAMs: Replacing Animal Testing in Drug Discovery

Dr. Thomas Hartung

Director, CAAT

Play 42:15
Cell Therapy Manufacturing: Scaling CAR-T to the Masses
Biotech
#157 2026-02-25

Cell Therapy Manufacturing: Scaling CAR-T to the Masses

Dr. Carl June

Director, Center for Cellular Immunotherapies

Play 48:40
Radiopharmaceuticals: The Targeted Radiation Gold Rush
Biotech
#158 2026-02-11

Radiopharmaceuticals: The Targeted Radiation Gold Rush

Dr. Ken Song

CEO & President

Play 45:18
The Obesity Drug Wars: Novo Nordisk vs Eli Lilly
Biotech
#159 2026-01-14

The Obesity Drug Wars: Novo Nordisk vs Eli Lilly

Dr. John Wilding

Professor of Diabetes & Endocrinology

Play 50:30
SMR Economics: NuScale's Path to Certification
Nuclear
#160 2026-05-06

SMR Economics: NuScale's Path to Certification

John Hopkins

CEO

Play 55:18
Nuclear Renaissance: Why Big Tech is Betting on Fission
Nuclear
#161 2026-04-22

Nuclear Renaissance: Why Big Tech is Betting on Fission

Bridget van Dorsten

Energy Analyst

Play 52:30
The World Bank Lifts Its Nuclear Ban: What It Means
Nuclear
#162 2026-04-08

The World Bank Lifts Its Nuclear Ban: What It Means

Sama Bilbao y León

Director General

Play 44:15
TerraPower's NRC Construction Permit: A Milestone
Nuclear
#163 2026-03-25

TerraPower's NRC Construction Permit: A Milestone

Chris Levesque

CEO

Play 48:22
Uranium Markets: Pricing, Supply, and the Fuel Cycle
Nuclear
#164 2026-03-11

Uranium Markets: Pricing, Supply, and the Fuel Cycle

Nick Touran

Nuclear Engineer

Play 46:10
Nuclear vs Data Centers: Powering the AI Boom
Nuclear
#165 2026-02-25

Nuclear vs Data Centers: Powering the AI Boom

Jake Jurewicz

CEO & Co-founder

Play 50:45
Prefab Nuclear: Blue Energy's Factory-Built Reactors
Nuclear
#166 2026-02-11

Prefab Nuclear: Blue Energy's Factory-Built Reactors

Jake Jurewicz

CEO & Co-founder

Play 47:30
China's Nuclear Buildout: 10 Reactors Per Year
Nuclear
#167 2026-01-28

China's Nuclear Buildout: 10 Reactors Per Year

Andrew Meehan

Nuclear Policy Analyst

Play 43:18
Nuclear Restart: Bringing Decommissioned Plants Back Online
Nuclear
#168 2026-01-14

Nuclear Restart: Bringing Decommissioned Plants Back Online

Regis Matzie

Nuclear Consultant

Play 41:22
The UK's SMR Bet: Rolls-Royce Wins Big
Nuclear
#169 2026-01-07

The UK's SMR Bet: Rolls-Royce Wins Big

Tom Samson

CEO

Play 39:45
Iron-Air Batteries at Scale: Form Energy's 100-Hour Storage
Energy Storage
#171 2026-05-13

Iron-Air Batteries at Scale: Form Energy's 100-Hour Storage

Mateo Jaramillo

CEO & Co-founder

Play 50:00
The 50 GW Milestone: US Storage Market Update 2026
Energy Storage
#172 2026-04-29

The 50 GW Milestone: US Storage Market Update 2026

Anna Darmani

Principal Analyst

Play 44:15
Sodium-Ion Batteries: The Cheap Alternative to Lithium
Energy Storage
#173 2026-04-15

Sodium-Ion Batteries: The Cheap Alternative to Lithium

Marek Kubik

Energy Storage Expert

Play 42:30
Grid Storage as Transmission: A New Paradigm
Energy Storage
#174 2026-04-01

Grid Storage as Transmission: A New Paradigm

Peter Kelly-Detwiler

Energy Analyst & Host

Play 46:08
Data Center Batteries: On-Site Storage for AI Loads
Energy Storage
#175 2026-03-18

Data Center Batteries: On-Site Storage for AI Loads

Noah Roberts

Executive Director

Play 41:15
China's 65 GWh Month: The Global Storage Arms Race
Energy Storage
#176 2026-03-04

China's 65 GWh Month: The Global Storage Arms Race

Tim Montague

Solar & Storage Analyst

Play 38:22
Solar-Plus-Storage: Why Half of All Solar Now Ships With Batteries
Energy Storage
#177 2026-02-18

Solar-Plus-Storage: Why Half of All Solar Now Ships With Batteries

Shawn Shaw

CEO & Author

Play 43:40
Long-Duration Storage: Beyond 4 Hours to 100 Hours
Energy Storage
#178 2026-02-04

Long-Duration Storage: Beyond 4 Hours to 100 Hours

Dan Shobert

Energy Storage Analyst

Play 47:55
Battery Safety: NFPA 855 and the 0.3% Fire Rate
Energy Storage
#179 2026-01-21

Battery Safety: NFPA 855 and the 0.3% Fire Rate

Paul Rogers

Fire Protection Engineer

Play 39:18
Humanoid Robots: Figure 03 and the $30K Production Mile
Robotics
#180 2026-05-20

Humanoid Robots: Figure 03 and the $30K Production Mile

Brett Adcock

Founder & CEO

Play 49:30
Tesla Optimus Gen 3: From Demo to Factory Floor
Robotics
#181 2026-05-06

Tesla Optimus Gen 3: From Demo to Factory Floor

Lars Moravy

Director of Robotics Engineering

Play 45:00
The Humanoid Boom: China's State-Backed Push to Dominate
Robotics
#182 2026-04-22

The Humanoid Boom: China's State-Backed Push to Dominate

Boris Sofman

Robotics Engineer & Analyst

Play 48:15
Warehouse Automation: Tote-to-Person and Multi-Agent Orchestration
Robotics
#183 2026-04-08

Warehouse Automation: Tote-to-Person and Multi-Agent Orchestration

John Santagate

Founder & Principal Consultant

Play 42:30
Embodied AI: When Robots Learn Like Children
Robotics
#184 2026-03-25

Embodied AI: When Robots Learn Like Children

Dr. Pieter Abbeel

Professor & Co-founder

Play 51:22
iRobot's Bankruptcy: What Went Wrong in Consumer Robotics
Robotics
#185 2026-03-11

iRobot's Bankruptcy: What Went Wrong in Consumer Robotics

Colin Angle

Former CEO & Co-founder

Play 40:15
Boston Dynamics and the Atlas Transition: Electric Hydraulics
Robotics
#186 2026-02-25

Boston Dynamics and the Atlas Transition: Electric Hydraulics

Robert Playter

CEO

Play 46:40
Dexterous Manipulation: The Last Frontier of Robotics
Robotics
#187 2026-02-11

Dexterous Manipulation: The Last Frontier of Robotics

Dr. Ken Goldberg

Professor of Industrial Engineering

Play 44:18
Agricultural Robots: Autonomous Farming at Scale
Robotics
#188 2026-01-28

Agricultural Robots: Autonomous Farming at Scale

Jorge Heraud

CEO & Co-founder

Play 41:30
Surgical Robotics: Beyond da Vinci to Autonomous Procedures
Robotics
#189 2026-01-14

Surgical Robotics: Beyond da Vinci to Autonomous Procedures

Dr. Fred Moll

Founder & Chief Development Officer

Play 47:12
Waymo's 15-City Expansion: Robotaxi Unit Economics
AV
#190 2026-04-29

Waymo's 15-City Expansion: Robotaxi Unit Economics

Tekedra Mawakana

Co-CEO

Play 41:25
2026: The Year of the Robotaxi
AV
#191 2026-04-15

2026: The Year of the Robotaxi

Alex Gunz

Future Trends Analyst

Play 44:15
End-to-End AI Driving: Wayve and Waabi's $2B Bet
AV
#192 2026-04-01

End-to-End AI Driving: Wayve and Waabi's $2B Bet

Alex Kendall

CEO & Co-founder

Play 52:30
Mercedes Drive Pilot L3: The Autonomous Highway Reality
AV
#193 2026-03-18

Mercedes Drive Pilot L3: The Autonomous Highway Reality

Markus Schäfer

CTO & Board Member

Play 40:00
NVIDIA Powers Uber: The Trillion-Dollar Self-Driving Stack
AV
#194 2026-03-04

NVIDIA Powers Uber: The Trillion-Dollar Self-Driving Stack

Gary Lapidus

AV Industry Analyst

Play 43:22
Autonomous Trucking: Dallas to Houston Without a Driver
AV
#195 2026-02-18

Autonomous Trucking: Dallas to Houston Without a Driver

Raquel Urtasun

CEO & Founder

Play 46:08
Zoox: The Purpose-Built Robotaxi Hits the Streets
AV
#196 2026-02-04

Zoox: The Purpose-Built Robotaxi Hits the Streets

Aicha Evans

CEO

Play 41:30
AV Regulation: The Federal vs State Patchwork
AV
#197 2026-01-21

AV Regulation: The Federal vs State Patchwork

Pat Tsen

Deputy Executive Director

Play 38:45
Autonomous Delivery: DoorDash, Drones, and Sidewalk Robots
AV
#198 2026-01-14

Autonomous Delivery: DoorDash, Drones, and Sidewalk Robots

Ashu Rege

VP of Autonomous Technology

Play 40:12
When Robotaxis Fail: Waymo's Flood Pause and Edge Cases
AV
#199 2026-01-07

When Robotaxis Fail: Waymo's Flood Pause and Edge Cases

Alain Kornhauser

Professor & Host, Smart Driving Cars

Play 37:18
The 1,000-Qubit Era: IBM's Condor and Beyond
Quantum
#201 2026-05-13

The 1,000-Qubit Era: IBM's Condor and Beyond

Jay Gambetta

VP, Quantum Computing

Play 1:05:00
Has Quantum Advantage Been Achieved? The Great Debate
Quantum
#202 2026-04-29

Has Quantum Advantage Been Achieved? The Great Debate

Dominik Hangleiter

Ambizione Fellow

Play 52:15
Quantum Meets AI: Allies Not Competitors
Quantum
#203 2026-04-15

Quantum Meets AI: Allies Not Competitors

Celia Merzbacher

Executive Director

Play 48:30
The Road to 40,000 Logical Qubits by 2030
Quantum
#204 2026-04-01

The Road to 40,000 Logical Qubits by 2030

Paul Terry

CEO

Play 55:22
Q-Day: When Quantum Breaks the Internet's Encryption
Quantum
#205 2026-03-18

Q-Day: When Quantum Breaks the Internet's Encryption

Marc Yoder

Field CISO

Play 46:18
Quantum Sensing: The Most Underrated Quantum Technology
Quantum
#206 2026-03-04

Quantum Sensing: The Most Underrated Quantum Technology

Dr. Jun Ye

Physicist & Fellow

Play 43:40
Quantum Chemistry: Simulating Molecules That Classical Computers Can't
Quantum
#207 2026-02-18

Quantum Chemistry: Simulating Molecules That Classical Computers Can't

Bert de Jong

Senior Scientist

Play 49:15
Quantum Funding: The Series A/B Gap
Quantum
#208 2026-02-04

Quantum Funding: The Series A/B Gap

Kris Naudts

Co-founder

Play 41:22
The Quantum Marathon: Why We're Still at the Start
Quantum
#209 2026-01-21

The Quantum Marathon: Why We're Still at the Start

Andre Koenig

Quantum Researcher & Commentator

Play 44:30
Programming Quantum Computers: Will AI Be the Interface?
Quantum
#210 2026-01-14

Programming Quantum Computers: Will AI Be the Interface?

Robert Wille

Professor & CEO

Play 42:08
The 100K GPU Cluster: Inside xAI's Memphis Supercomputer
AI
#241 2026-07-15

The 100K GPU Cluster: Inside xAI's Memphis Supercomputer

Greg Yang

Co-founder & SVP Engineering

Play 1:15:00
Autonomous Weapons: The Ethics of AI in Warfare
AI
#242 2026-07-22

Autonomous Weapons: The Ethics of AI in Warfare

Paul Scharre

Executive VP & Director of Studies

Play 1:00:00
Blue Origin New Glenn: Finally Orbiting
Space
#243 2026-08-05

Blue Origin New Glenn: Finally Orbiting

Jarrett Jones

SVP, New Glenn

Play 1:10:00
The Quantum Workforce: Who Owns the Quantum Plan?
Quantum
#244 2026-08-12

The Quantum Workforce: Who Owns the Quantum Plan?

Brad Pollard

Field CTO

Play 48:00
Women's Health and ARPA-H: Reimagining Maternal Care
Biotech
#245 2026-08-19

Women's Health and ARPA-H: Reimagining Maternal Care

Dr. Renee Wegrzyn

Director

Play 45:00
Oklo's Fast Reactor: The Aurora Houseplant Power Plant
Nuclear
#246 2026-08-26

Oklo's Fast Reactor: The Aurora Houseplant Power Plant

Jacob DeWitte

CEO & Co-founder

Play 48:00
May Mobility's Robotaxi Deal: Geofenced Autonomy at Work
AV
#247 2026-09-02

May Mobility's Robotaxi Deal: Geofenced Autonomy at Work

Edwin Olson

CEO & Founder

Play 40:00
X-Energy's IPO and the Advanced Reactor Investment Landscape
Nuclear
#248 2026-09-09

X-Energy's IPO and the Advanced Reactor Investment Landscape

Clay Sell

CEO

Play 50:00
Behind the Meter: Google's $4.75B Solar-Storage Acquisition
Energy Storage
#249 2026-09-16

Behind the Meter: Google's $4.75B Solar-Storage Acquisition

Shawn Shaw

CEO & Author

Play 42:00
Precision Neuroscience: The BCI That Maps the Brain in 15 Minutes
BCI
#250 2026-09-23

Precision Neuroscience: The BCI That Maps the Brain in 15 Minutes

Ben Rapoport

CEO & Co-founder

Play 44:00
FEOC Compliance: The $100/kWh Chinese Battery Dilemma
Energy Storage
#251 2026-09-30

FEOC Compliance: The $100/kWh Chinese Battery Dilemma

John Weaver

Energy Storage Analyst

Play 38:00
The Future of Fusion: A 2027 Outlook Panel
Fusion
#252 2026-10-07

The Future of Fusion: A 2027 Outlook Panel

Dr. Melanie Windridge

Fusion Communicator & Physicist

Play 1:00:00
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